|
KMID : 0613820110210020316
|
|
Journal of Life Science
2011 Volume.21 No. 2 p.316 ~ p.321
|
|
|
Tryptophan Metabolite 3-Hydroxyanthranilic Acid Augments TRAIL-Induced Apoptosis in Activated T Cells
|
|
Seo Su-Kil
|
|
|
Abstract
|
|
|
|
Generation of tryptophan-derived metabolites by indoleamine 2,3-dioxygenase (IDO) is a potent immunoregulatory mechanism in T cell responses. However, the mechanism remains unclear. We showed that 3-hydroxyanthranilic acid (3-HAA), the most potent metabolite, selectively induced apoptosis in activated T cells, but not in resting T cells. This was not associated with cell cycle arrest. We found that TRAIL expression was selectively induced in activated T cells by treatment of 3-HAA. Blockade of the TRAIL: DR4/DR5 pathway significantly inhibited 3-HAA-mediated T cell death. Our data suggest that TRAIL-induced apoptosis is involved in the mechanism of 3-HAA-mediated T cell death.
|
|
|
KEYWORD
|
|
|
Indoleamine 2, 3-dioxygenase, 3-hydroxyanthranilic acid, T cell, TNF-related apoptosisinducing ligand
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|